Publications

Year 2002

  Chieffi P. 1-2, Colucci- D'Amato G.L. 2-3, Guarino F. 4, Salvatore G. 5, Angelini F. 4 17-beta estradiol induces spermatogonial proliferation through Mitogen Activated Protein Kinase (Extracellular Signal Regulated Kinase 1/2) activity in the lizard (podarcis s. Sicula) Bifulco M., Laezza C., Stingo S., Wolff J. 2', 3'-Cyclic nucleotide 3'-phosphodiesterase: a membrane-bound, microtubule-associated protein and membrane anchor for tubulin. Le Hir H. 1, Charlet-Berguerand N. 1, De Franciscis V. 2, Thermes C. 1 5'-End ret splicing: absence of variants in normal tissues and intron retention in pheochromocytomas. Cardone L., De Cristofaro T., Affaitati A., Garbi C., Ginsberg M. D., Saviano M., Varrone S., Rubin C. S., Gottesman M E., Avvedimento E V., Feliciello A. A-kinase anchor protein 84/121 are targeted to mitochondria and mitotic spindles by overlapping amino-terminal motifs Guagliardi A., Cerchia L., Rossi M. An intracellular protease of the crenarchaeon Sulfolobus solfataricus which has sequence homology with eukaryotic peptidases of CD clan. Chieffi P., Colucci-DAmato G.L and Tramontano D. Annual profile of MAPK (ERK1/2) in the frog (rana esculenta) testis Fusco A., Chiappetta G., Hui P., Garcia-Rostan G., Golden L., Kinder Bk, Dillon D., Giuliano A., Cirafici A., Santoro M., Rosai J., Tallini G. Assessment of RET/PTC oncogene activation and clonality in thyroid nodules with incomplete morphological evidence of papillary carcinoma: a search for the early precursors of papillary cancer. Matarese G., La Cava A., Sanna V., Lord Gm, Lechler R., Fontana S., Zappacosta S. Balancing susceptibility to infection and autoimmunity: a role for leptin? Farooqi I.S. 1, Matarese G. 2, Lord G.M. 3, Keogh J.M. 1, Lawrence E. 4, Agwu C. 5, Sanna V. 2, Jebb S.A. 6, Perna F. 7, Fontana S. 2, Lechler R.I. 3, De Paoli A.M. 4, O'Rahilly S. 1 Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. Curci A, Capasso I, Romano A, Bruni P, Motti ML, Pignata S, D'Aiuto G, Casamassimi A, D'Urso M, Fusco A, Viglietto G. Characterization of 2 novel and 2 recurring BRCA1 germline mutations in breast and/or ovarian carcinoma patients from the area of Naples. Viglietto G. 1, Motti M.L. 1, Bruni P. 2, Melillo R.M. 1, D'Alessio A. 3, Califano D. 3, Vinci F. 4, Chiappetta G. 3, Tsichlis P. 5, Bellacosa A. 6-7, Fusco A. 1, Santoro M. 1 Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer. Terrazzano G., Zanzi D., Palomba C., Carbone E., Grimaldi S., Pisanti S., Fontana S., Zappacosta S., Ruggiero G. Differential involvement of CD40, CD80, and major histocompatibility complex class I molecules in cytotoxicity induction and interferon-gamma production by human natural killer effectors. Lipardi C., Ruggiano G., Perrone L., Paladino S., Monlauzeur L., Nitsch L., Le Bivic A., Zurzolo C. Differential recognition of a tyrosine-dependent signal in the basolateral and endocytic pathways of thyroid epithelial cells. Mondola P., Seru R., Santillo M., Damiano S., Bifulco M., Laezza C., Formisano P., Rotilio G., Ciriolo M. Effect of Cu, Zn superoxide dismutase on cholesterol metabolism in human hepatocarcinoma (hepg2) cells. Ricchi, P., Di Matola, T., Ruggiero, G., Zanzi, D., Apicella, A., Di Palma, A., Pensabene, M., Pignata, S., Zarrilli, R., Acquaviva, A.M. Effect of non-steroidal anti-inflammatory drugs on colon carcinoma Caco-2 cell responsiveness to topoisomerase inhibitor drugs. Leonardi A., Vito P., Mauro C., Pacifico F., Ulianich L., Consiglio E., Formisano S., Di Jeso B. Endoplasmic reticulum stress causes Thyroglobulin retention in this organelle and triggers activation of NF-kb via TNF-Receptor Associated Factor 2 (TRAF2). Postiglione L., Montagnani S., Riccio A., Montuori N., Sciorio S., Ladogana P., Spigna G.D., Castaldo C., Rossi G. Enhanced expression of the receptor for granulocyte macrophage colony stimulating factor on dermal fibroblasts from scleroderma patients. Sinisi A.A., Chieffi P., Pasquali D., Kisslinger A., Staibano S., Bellastella A., Tramontano D. EPN: a novel epithelial cel line derived from human prostate tissue. Bracale A., Spalletti-Cernia D., Mastronicola M., Castaldi F., Mannucci R., Nitsch L., D'Alessio G. Essential stations in the intracellular pathway of cytotoxic bovine seminal ribonuclease. Basolo F. 1, Giannini R. 1, Toniolo A. 4, Casalone R. 4, Nikiforova M. 6, Pacini F. 2, Elisei R. 2, Miccoli P.3, Berti P. 3, Faviana P. 1, Fiore L. 1, Monaco C. 5, Pierantoni G. M. 5, Fedele M. 5, Nikiforov Ye 6, Santoro M. 5, Fusco A. 5 Establishment of a non-tumorigenic papillary thyroid cell line (FB-2) carrying the RET/PTC1 rearrangement. Salvatore G. 1-2, Nagata S. 1, Billaud M. 3, Santoro M. 2, Vecchio G. 2, Pastan I. 1 Generation and characterization of novel monoclonal antibodies to the Ret receptor tyrosine kinase. Baldassarre G. 1, Bruni P. 2, Boccia A. 3, Salvatore G. 3, Melillo R.M. 3, Motti M.L. 3, Napolitano M. 1, Belletti B. 1, Fusco A. 3, Santoro M. 3, Viglietto G. 3 Glial cell line-derived neurotrophic factor induces proliferative inhibition of NT2/D1 cells through RET-mediated up-regulation of the cyclin-dependent kinase inhibitor p27(kip1). Bifulco G., Di Carlo C., Caruso M., Oriente F., Di Spiezio Sardo A., Formisano P., Beguinot F., Nappi C. Glucose regulates insulin mitogenic effect by modulating SHP-2 activation and localization in jar cells. Mascia A. 1, Nitsch L. 1, Di Lauro R. 1, Zannini M. 1 Hormonal control of the transcription factor Pax8 and its role in the regulation of thyroglobulin gene expression in thyroid cells. Buono P., Cassano S., Alfieri A., Mancini A., Salvatore F. Human aldolase C gene expression is regulated by adenosine 3', 5'-cyclic monophosphate (camp) in PC12 cells. Indolfi C., Di Lorenzo E., Perrino C., Stingone A., Curcio A., Torella D., Cittadini A., Cardone L., Coppola C., Cavuto L., Arcucci O, Sacca L., Avvedimento E., Chiariello M. Hydroxymethylglutaryl coenzyme A reductase inhibitor simvastatin prevents cardiac hypertrophy induced by pressure overload and inhibits p21ras activation. Pianese L., Tammaro A., Turano M., De Biase I., Monticelli A., Cocozza S. Identification of a novel transcript of X25, the human gene involved in Friedreich ataxia Salvatore G., Beers R., Margulies I, Kreitman R.J., Pastan I. Improved cytotoxic activity toward cell lines and fresh leukemia cells of a mutant anti-CD22 immunotoxin obtained by antibody phage display. Martelli M.L. 1, Iuliano R. 1, Le Pera I. 1, Sama' I.1, Monaco C. 2, Cammarota S. 2, Kroll T. 3, Chiariotti L. 1, Santoro M. 2, Fusco A. 1-2 Inhibitory effects of peroxisome poliferator-activated receptor gamma on thyroid carcinoma cell growth. Matarese G. 1, Sanna V. 2, Lechler R. 3, Sarvetnick N. 4, Fontana S. 2, Zappacosta S. 1, La Cava A. 4 Leptin accelerates autoimmune diabetes in female NOD mice. Matarese G. 2, Sanna V. 2, Lechler R.I. 3, Sarvetnick N. 4, Fontana S. 2, Zappacosta S. 1, La Cava A. 4 Leptin accelerates onset and progression of autoimmune diabetes in the nonobese diabetic (NOD) mouse. Farooqi S., Matarese G., Lord GM., Keogh JM., Lawrence E., Agwu C., Sanna V., Jebb SA., Perna F., Fontana S., Lechler RI, Depaoli AM., O'Rahilly S. Leptin administration has sustained beneficial effects on the obesity, T cell hyporesponsiveness and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. Matarese G., Sanna V., Fontana S., Zappacosta S. Leptin as a novel therapeutic target for immune intervention. Lord G., Matarese G., Howard J., Bloom S., Lechler R. Leptin inhibits the anti-CD3-driven proliferation of peripheral blood T cells but enhances the production of proinflammatory cytokines. Valentino R., Savastano S., Maglio M., Paparo F., Ferrara F., Dorato M., Lombardi G., Troncone R. Markers of potential coeliac disease in patients with Hashimoto's thyroiditis. Gallo A., Cuozzo C., Esposito I., Maggiolini M., Bonfiglio D., Vivacqua A., Garramone M., Weiss C. Bohmann D., Musti A.M. Menin uncouples Elk-1, Jun D and cjun phosphorylation from MAP kinase activation Candotti F; Notarangelo L; Visconti R; O'Shea JJ Molecular aspects of primary immunodeficiencies: lessons from cytokine and other signaling pathways Santoro M., Melillo R., Carlomagno F., Fusco A., Vecchio G. Molecular mechanisms of RET activation in human cancer. Condorelli G. 1, Trencia A. 1, Vigliotta G. 1, Perfetti A. 1, Goglia U. 1, Cassese A. 1, Musti A.M. 1-2, Miele C. 1, Santopietro S. 1, Formisano P. 1, Beguinot F. 1 Multiple members of the mitogen-activated protein kinase family are necessary for PED/PEA-15 anti-apoptotic function. Cerchia L. 1, Hamm J. 2, Libri D. 3, Tavitian B. 4, De Franciscis V. 1 Nucleic acid aptamers in cancer medicine. Lilliu V, Perrone-Capano C, Pernas-Alonso R, Diaz Trelles R, Luca Colucci d'Amato G, Zuddas A, di Porzio U. Ontogeny of kainate receptor gene expression in the developing rat midbrain and striatum Fedele M. 1-2, Battista S. 1-2, Kenyon L. 3, Baldassarre G. 2, Fidanza V. 2, Klein-Szanto A.J. 4, Parlow A.F. 5, Visone R. 1, Pierantoni G.M. 1, Outwater E. 6, Santoro M. 1, Croce C.M. 2, Fusco A. 1-7 Overexpression of the HMGA2 gene in transgenic mice leads to the onset of pituitary adenomas. Bera T., Maitra R., Iavarone C., Salvatore G., Kumar V., Vincent J., Sathyanarayana B., Duray P., Lee B., Pastan I PATE, a gene expressed in prostate cancer, normal prostate, and testis, identified by a functional genomic approach. Pero R. 1, Lembo F. 1, Palmieri E. 1, Vitiello C. 1, Fedele M. 1, Fusco A. 1, Bruni C. 1, Chiariotti L. 2 PATZ attenuates the RNF4-mediated enhancement of androgen receptor-dependent transcription. Franchimont D; Galon J; Vacchio MS; Fan S; Visconti R; Frucht DM; Geenen V; Chrousos GP; Ashwell JD; O'Shea JJ Positive Effects of Glucocorticoids on T Cell Function by Up-Regulation of IL-7 Receptor alpha Montuori N. 1, Rossi G. 2, Ragno P. 1 Post-transcriptional regulation of gene expression in the plasminogen activation system. Basolo F. 1, Giannini R. 1, Monaco C. 5, Melillo R.M. 5, Carlomagno F. 5, Pancrazi M. 1, Salvatore G. 5, Chiappetta G. 4, Pacini F. 2, Elisei R. 2, Miccoli P. 3, Pinchera A. 2, Fusco A. 5, Santoro M. 5 Potent mitogenicity of the RET/PTC3 oncogene correlates with its prevalence in tall-cell variant of papillary thyroid carcinoma. Picascia A. Stanzione S., Chieffi P., Kisslinger A., Dickic I., Tramontano D. Proline-rich kinase 2regulates proliferation and differentiation of prostate cells Cuda G., Paternr R., Ceravolo R., Condigliota M., Perrotti N., Faniello M.C., Schepis F., Bifulco M., Perticone F., Cassano S., Ruocco A., Santillo M.R., Avvedimento V.E. Protection of human endothelial cells from oxidative stress. Role of Ras-ERK1/2 signalling. Sarnataro D., Paladino S., Campana V., Grassi J., Nitsch L., Zurzolo C. Prpc is sorted to the basolateral membrane of epithelial cells independently of its association with rafts. Chiariello M., Gutkind J.S. Regulation of MAP Kinases by G Protein-Coupled Receptors Santoro M. 1, Papotti M. 2, Chiappetta G. 3, Garcia-Rostan G. 4, Volante M. 2, Johnson C., Camp R.L. 6, Pentimalli F. 1, Monaco C. 1, Herrero A. 2, Carcangiu M.l. 5, Fusco A. 1, Tallini G. 6 RET activation and clinicopathologic features in poorly differentiated thyroid tumors. Collins B.J. 1-3, Chiappetta G. 2, Schneider A.B. 1-3, Santoro M. 4, Pentimalli F. 4, Fogelfeld L. 3, Gierlowski T. 3, Shore-Freedman E. 1-3, Jaffe G. 3, Fusco A. 4 RET expression in papillary thyroid cancer from patients irradiated in childhood for benign conditions. De Gregorio E., Abrescia C., Carlomagno M.S., Di Nocera PP RNA hairpins formed by nemis DNA repeats are cleaved by ribonuclease III in Neisseriae Postiglione M.P., Parlato R., Rodriguez-Mallon A., Rosica A., Mithbaokar P., Maresca M., Marians R.C., Davies T.F., Zannini M., De Felice M., Di Lauro R. Role of the thyroid stimulating hormone receptor signalling in development and differentiation of the thyroid gland. Matarese G. 1, Castelli-Gattinara G. 3, Cancrini C. 3, Bernardi S. 3, Romiti M.L. 3, Savarese C. 1, Di Giacomo A. 2, Rossi P. 3, Racioppi L. 1 Serum leptin and CD4+ T lymphocytes in HIV+ children during highly active antiretroviral therapy. Morinobu A; Gadina M; Strober W; Visconti R; Fornace A; Montagna C; Feldman GM; Nishikomori R; O'Shea JJ STAT4 serine phosphorylation is critical for IL-12-induced IFN-? production but not for cell proliferation Morinobu A., Gadina M., Strober W., Visconti R., Fornace A., Montagna C., Feldman G.M., Nishikomori R., O'Shea J.J. STAT4 serine phosphorylation is critical for IL-12-induced IFN-W production but not for cell proliferation. Montuori N. 1, Carriero M.V. 2, Salzano S. 1, Rossi G. 1-3, Ragno P. 1 The cleavage of the urokinase receptor regulates its multiple functions. Finelli P. 1, Pierantoni G.M. 2, Giardino D. 1, Losa M. 3, Rodeschini O. 1, Fedele M. 2, Valtorta E. 1, Mortini P. 3, Croce C.M. 4, Larizza L. 1-5, Fusco A. 2 The High Mobility Group A2 gene is amplified and overexpressed in human prolactinomas. Pierantoni GM, Bulfone A, Pentimalli F, Fedele M, Iuliano R, Santoro M, Chiariotti L, Ballabio A, Fusco A. The homeodomain-interacting protein kinase 2 gene is expressed late in embryogenesis and preferentially in retina, muscle, and neural tissues. Carlomagno F, Vitagliano D, Guida T, Napolitano M, Vecchio G, Fusco A, Gazit A, Levitzki A, Santoro M. The kinase inhibitor PP1 blocks tumorigenesis induced by RET oncogenes. Pelicci G. 1, Troglio F. 1, Bodini A. 1, Melillo R.M. 2, Pettirossi V. 1, Coda L. 1, De Giuseppe A. 3, Santoro M. 2, Pelicci P.G. 1-4-5 The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret to the phosphatidylinositol 3-kinase/Akt signaling pathway. Chiappetta G. 1, Toti P. 2, Cetta F. 3, Giuliano A. 1, Pentimalli F. 4, Amendola I. 1-4, Lazzi S. 2, Monaco M. 1, Mazzuchelli L. 5, Tosi P. 2, Santoro M. 4, Fusco A. 4 The RET/PTC oncogene is frequently activated in oncocytic thyroid tumors (Hurthle cell adenomas and carcinomas), but not in oncocytic hyperplastic lesions. Nezi L., Greco D., Nitsch L., Garbi C. The role of proteases in fibronectin matrix remodeling in thyroid epithelial cell monolayer cultures. Berlingieri M.T. 1, Pierantoni G.M. 1, Giancotti V. 2, Santoro M. 1, Fusco A. 1 Thyroid cell transformation requires the expression of the HMGA1 proteins. Creemers L., Meng X, Den Ouden K, Van Pelt A., Izadyar F., Santoro M., Sariola H, De Rooij D. Transplantation of germ cells from glial cell line-derived neurotrophic factor-overexpressing mice to host testes depleted of endogenous spermatogenesis by fractionated irradiation. Stilo R., Leonardi, A., Formisano, L., Di Jeso, B., Vito, P., Liguoro, M. TUCAN/CARDINAL and DRAL partecipate in a common pathway for modulation of NF-kb activation. Xiao C., Yang B., Asadi N., Beguinot F., Hao C. Tumor necrosis factor-related apoptosis-inducing ligand-induced death-inducing signaling complex and its modulation by c-FLIP and PED/PEA-15 in glioma cells. Pianese L. 1-2, Busino L. 2, De Biase I 2, De Cristofaro T. 3, Lo Casale M.S. 1-2, Giuliano P. 1-2, MONTICELLI A. 3, Turano M. 1-2, Criscuolo C. 4, Filla A. 4, Varrone S. 2, Cocozza S. 2 Up-regulation of c-Jun N-terminal kinase pathway in Friedreich's ataxia cells. Silvestro A., Scopacasa F., Oliva G., De Cristofaro T., Iuliano L., Brevetti G. Vitamin C prevents endothelial dysfunction induced by acute exercise in patients with intermittent claudication. Carlomagno F. 1, Vitagliano D. 1, Guida T. 1, Ciardiello F. 2, Tortora G. 2, Fontanini G. 3, Vecchio G. 1, Ryan A. 4, Fusco A. 1, Santoro M. 1 ZD6474, an Orally Available Inhibitor of KDR Tyrosine Kinase Activity, Efficiently Blocks Oncogenic RET Kinases.