Veronica De Rosa
Ricercatore - Group Leader

Via S. Pansini 5 80131 Napoli-Italia

+ 39-0817464671

veronica.derosa@cnr.it

L'attività di ricerca della Dr.ssa De Rosa si propone di valutare se modifiche epigenetiche o trascrizionali del Foxp3, fattore specifico delle cellule T regolatorie (Treg), può compromettere la genesi e / o la funzione delle Treg, con conseguente alterazione dell'omeostasi linfocitaria e della tolleranza periferica. I suoi studi cercano di svelare i meccanismi molecolari che controllano l'espressione del Foxp3 e l'omeostasi delle Treg, offrendo dunque nuove opportunità di investigazione utili alla comprensione dei meccanismi patogenetici che caratterizzano le patologie immuno-mediate, quali autoimmunità, immunodeficienze e cancro.

Curriculum Vitae

PERSONAL INFORMATION

Family name, First name: De Rosa, Veronica

Researcher unique identifier(s): orcid.org/0000-0002-9477-0991

Date of birth: 14/11/1979

Nationality: Italian                       

  • EDUCATION

07/02/2008       PhD in Molecular Endocrinology and Oncology at Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università di Napoli “Federico II”, Napoli, Italy;                     

29/10/2002       Degree in Biotechnology, with top score – Summa Cum Laude at Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università di Napoli “Federico II”, Napoli, Italy;

1992-1997        Scientific College (Math-Latin), at Liceo Scientifico “A.M. De Carlo”, Napoli.

  • CURRENT POSITION

From 16/11/2016          Permanent Researcher, Group Leader at the Laboratory of Immunology, Istituto per l'Endocrinologia e l'Oncologia Sperimentale del Consiglio Nazionale delle Ricerche (IEOS-CNR), Napoli,Italy;     

  • PREVIOUS POSITIONS

2008 – 2016     Non-Permanent Researcher (RTD-CNR) at the Laboratory of Immunology, Istituto per l'Endocrinologia e l'Oncologia Sperimentale del Consiglio Nazionale delle Ricerche (IEOS-CNR), Napoli, Italy;

March 2008     Post-Doc CNR-Research Contract, Istituto per l'Endocrinologia e l'Oncologia Sperimentale del Consiglio Nazionale delle Ricerche (IEOS-CNR), Napoli, Italy;

2004 – 2008     PhD-Fellow Università di Napoli Federico II, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università di Napoli “Federico II”, Napoli, Italy;

2006                Research Associate (during PhD Program), Laboratory of Immune Regulation, Department of Medicine, David Geffen School of Medicine, University California Los Angeles, Los Angeles, USA.

  • FELLOWSHIPS

2003 – 2004      Fellowship from Fondazione Italiana Sclerosi Multipla (FISM), Dipartimento di di Biologia e Patologia Cellulare e Molecolare, Università di Napoli “Federico II”, Napoli, Italy.

 

  • SUPERVISION AND CO-SUPERVISION OF STUDENTS AND POSTDOCTORAL FELLOWS

2012 – 2016              Alessandra Colamatteo, PhD Student Traslational Medicine Program, Università di Salerno, Salerno, Italy;

2012 – 2016    Marianna Santopaolo, PhD Student Cellular and Molecular Pathology Program, Università di Napoli Federico II, Napoli, Italy;

2011 – 2014     Claudia La Rocca, PhD Student, Cellular and Molecular Pathology Program, Università di Napoli Federico II, Napoli, Italy;

2009 – 2012     Fortunata Carbone, PhD Student, Cellular and Molecular Pathology Program, Università di Napoli Federico II, Napoli, Italy;

2003 – 2006     Daniela Aufiero, Master in Science – Laboratory Techniques, Università di Napoli Federico II, Napoli, Italy.

  • TEACHING ACTIVITIES

2012 – 2015     Lecturer at EFIS Ceppellini School of Immunology, Course on Immunity in Human Pathology, Napoli, Italy;

2009 – 2010     Research Contract-Professor of Basic Immunolgy at the Faculty of Pharmacy, Course on Allergology and Immunohematology, Università di Salerno, Salerno, Italy.

  • MEMBERSHIPS OF SCIENTIFIC SOCIETIES

2005 – Present             Member, Italian Society of Immunology, Clinical Immunology and Allergology (SIICA);

2005 – Present             Member, EFIS Superior School of Immunology “Ruggero Ceppellini”;

2005 – Present             Member, Italian Association of NeuroImmunology (AINI);

  • GRANTS as Principal Investigator/Coordinator

2019 – 2023           Grant PRIN 2017, Settore LS6 Linea B (2017K7FSYB_004) entitled: “Stromal- immune cell crosstalk in the generation of tertiary lymphoid structure in solid cancers: immunometabolic aspects and implications for cancer therapy”. Role: PI, Coordinator Unit 4;

2019 – 2022           Grant of Fondazione Italiana Sclerosi Multipla (FISM) (2018/R4) entitled: “Ruolo delle vescicole extracellulari nella regolazione dell’espressione del Foxp3 e della funzione soppressoria in cellule T regolatorie nella sclerosi multipla. Role: PI;

2019 – 2021           Grant STARL1-2018 entitled: “Epigenetic control of immune tolerance: a key role for chromatin remodeling event in Foxp3 gene expression in health and autoimmunity”. Role: PI;

2018 – 2021           Grant Ricerca Finalizzata Giovani Ricercatori Ministero della Salute (GR-2016- 02363725) entitled: “Immune Tolerance, Metabolism and Multiple Sclerosis: Novel Molecular Tools to Monitor Disease Pathogenesis and Progression”. Role: Co-PI;

2016 – 2018           Grant TRIDEO (Transforming Ideas in Oncological research,17447) Associazione Italiana per la Ricerca sul Cancro (AIRC) entitled:"Unveiling thE role of FoxP3 splicing variants in regulatory T cells (Tregs) from subjects with breast cancer". Role: PI-Coordinator.

2015 – 2018           Grant of Fondazione Italiana Sclerosi Multipla (FISM) (2014/R/21) entitled: "Unveiling the role of ANXA1 in Multiple Sclerosis: identification of an endogenous factor decoding T cell breach of the blood brain barrier and immune tolerance" Role: PI-Coordinator of the Unit n.2.

2013 – 2016           Grant FIRB-Futuro in Ricerca (RBFR12I3UB_004, call 2012) of the MIUR (Ministero dell'Istruzione, dell'Università e della Ricerca) entitled:"Molecular pathways at the interface between immune and metabolic regulation leading to chronic inflammation and autoimmunity".  Role: PI-Coordinator of the Unit n.4.

2012 – 2015           Grant Ricerca Finalizzata Giovani Ricercatori Ministero della Salute, Bando 2010 (104/GR-2010-2315414) entitled: “mTOR-dependent oscillatory metabolic switch controlling self-immune tolerance”. Role: PI-Coordinator.

  • PRIZES AND AWARDS
  • Mosaic of Autoimmunity Award (MAI) as the best young researcher in the field of multiple sclerosis in Europe (2020);
  • Rita Levi Montalcini Prize for the best research in multiple sclerosis, AISM (Associazione Italiana Sclerosi Multipla) (2018);
  • Rotary Club Young Researchers Prize, Napoli (2015);
  • Harlan Prize of Experimental Immunology (2007);
  • 4th PBI International-Prize for the study on cytokines (2006);
  • Fellow of the Molecular Oncology and Endocrinology PhD Program, Università di Napoli Federico II (2004).

  

  • PUBLICATIONS

            Dr. De Rosa has n. 59 international publications, with H-index 28 (Scopus), n. 5251 total citations:

  1. Palma C, La Rocca C, Gigantino V, Aquino G, Piccaro G, Di Silvestre D, Brambilla F, Rossi R, Bonacina F, Lepore MT, Audano M, Mitro N, Botti G, Bruzzaniti S, Fusco C, Procaccini C, De Rosa V, Galgani M, Alviggi C, Puca A, Grassi F, Rezzonico-Jost T, Norata GD, Mauri P, Netea MG, de Candia P, Matarese G. Caloric Restriction Promotes Immunometabolic Reprogramming Leading to Protection from Tuberculosis.Cell Metab. 2021 Jan 4:S1550-4131(20)30671-9. doi: 10.1016/j.cmet.2020.12.016. Online ahead of print.
  2. Li X, Colamatteo A, Kalafati L, Kajikawa T, Wang H, Lim JH, Bdeir K, Chung KJ, Yu X, Fusco C, Porcellini A, De Simone S, Matarese G, Chavakis T, De Rosa V, Hajishengallis G.  The DEL-1/β3 integrin axis promotes regulatory T cell responses during inflammation resolution. J Clin Invest. 2020 Dec 1;130(12):6261-6277. doi: 10.1172/JCI137530.
  3. Terrazzano G, Bruzzaniti S, Rubino V, Santopaolo M, Palatucci AT, Giovazzino A, La Rocca C, de Candia P, Puca A, Perna F, Procaccini C, De Rosa V, Porcellini C, De Simone S, Fattorusso V, Porcellini A, Mozzillo E, Troncone R, Franzese A, Ludvigsson J, Matarese G, Ruggiero G, Galgani M. T1D progression is associated with loss of CD3+CD56+ regulatory T cells that control CD8+ T cell effector functions. Nat Metab. 2020 Feb;2(2):142-152. doi: 10.1038/s42255-020-0173-1. Epub 2020 Feb 17.
  4. Sheikh MH, Henson SM, Loiola RA, Mercurio S, Colamatteo A, Maniscalco GT, De Rosa V, McArthur S, Solito E. Immuno-metabolic impact of the multiple sclerosis patients' sera on endothelial cells of the blood-brain barrier. J Neuroinflammation. 2020 May 9;17(1):153. doi: 10.1186/s12974-020-01810-8.
  5. Colamatteo A, Carbone F, Bruzzaniti S, Galgani M, Fusco C, Maniscalco GT, Di Rella F, de Candia P, De Rosa V. Molecular Mechanisms Controlling Foxp3 Expression in Health and Autoimmunity: From Epigenetic to Post-translational Regulation. Front Immunol. 2020 Feb 3;10:3136. doi: 10.3389/fimmu.2019.03136. eCollection 2019.
  6. Colamatteo A, Micillo T, Bruzzaniti S, Fusco C, Garavelli S, De Rosa V, Galgani M, Spagnuolo MI, Di Rella F, Puca AA, de Candia P, Matarese G. Metabolism and Autoimmune Responses: The microRNA Connection. Front Immunol. 2019 Aug 28;10:1969.
  7. Colamatteo A, Maggioli E, Azevedo Loiola R, Hamid Sheikh M, Calì G, Bruzzese D, Maniscalco GT, Centonze D, Buttari F, Lanzillo R, Perna F, Zuccarelli B, Mottola M, Cassano S, Galgani M, Solito E, De Rosa V. Reduced Annexin A1 Expression Associates with Disease Severity and Inflammation in Multiple Sclerosis Patients. J Immunol. 2019 Oct 1;203(7):1753-1765.
  8. de Candia P, Prattichizzo F, Garavelli S, De Rosa V, Galgani M, Di Rella F, Spagnuolo MI, Colamatteo A, Fusco C, Micillo T, Bruzzaniti S, Ceriello A, Puca AA, Matarese G. Type 2 Diabetes: How Much of an Autoimmune Disease? Front Endocrinol (Lausanne). 2019 Jul 4;10:451.
  9. Bruzzaniti S, Bocchino M, Santopaolo M, Calì G, Stanziola AA, D'Amato M, Esposito A, Barra E, Garziano F, Micillo T, Zuchegna C, Romano A, De Simone S, Zuccarelli B, Mottola M, De Rosa V, Porcellini A, Perna F, Matarese G, Galgani M. An immunometabolic pathomechanism for chronic obstructive pulmonary disease. Proc Natl Acad Sci U S A. 2019 Jul 30;116(31):15625-15634.
  10. Stampanoni Bassi M, Iezzi E, Buttari F, Gilio L, Simonelli I, Carbone F, Micillo T, De Rosa V, Sica F, Furlan R, Finardi A, Fantozzi R, Storto M, Bellantonio P, Pirollo P, Di Lemme S, Musella A, Mandolesi G, Centonze D, Matarese G. Obesity worsens central inflammation and disability in multiple sclerosis. Mult Scler. 2019 Jun 4:1352458519853473.
  11. Garavelli S, De Rosa V, de Candia P. The Multifaceted Interface Between Cytokines and microRNAs: An Ancient Mechanism to Regulate the Good and the Bad of Inflammation. Front Immunol. 2018 Dec 21;9:3012.
  12. Sambucci M, Gargano F, De Rosa V, De Bardi M, Picozza M, Placido R, Ruggieri S, Capone A, Gasperini C, Matarese G, Battistini L, Borsellino G.  FoxP3 isoforms and PD-1 expression by T regulatory cells in multiple sclerosis. Sci Rep. 2018 Feb 27;8(1):3674. doi: 10.1038/s41598-018-21861-5.
  13. Kishore M, Cheung KCP, Fu H, Bonacina F, Wang G, Coe D, Ward EJ, Colamatteo A, Jangani M, Baragetti A, Matarese G, Smith DM, Haas R, Mauro C, Wraith DC, Okkenhaug K, Catapano AL, De Rosa V, Norata GD, Marelli-Berg FM. Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis. Immunity. 2017 Nov 21;47(5):875-889.e10;
  14. La Rocca C, Carbone F, De Rosa V, Colamatteo A, Galgani M, Perna F, Lanzillo R, Brescia Morra V, Orefice G, Cerillo I, Florio C, Maniscalco GT, Salvetti M, Centonze D, Uccelli A, Longobardi S, Visconti A, Matarese G. Immunometabolic profiling of T cells from patients with relapsing-remitting multiple sclerosis reveals an impairment in glycolysis and mitochondrial respiration. Metabolism. 2017 Dec;77:39-46;
  15. De Rosa V, La Cava A, Matarese G. Metabolic pressure and the breach of immunological self-tolerance. Nat Immunol. 2017 Oct 18;18(11):1190-1196;
  16. Lanzillo R, Carbone F, Quarantelli M, Bruzzese D, Carotenuto A, De Rosa V, Colamatteo A, Micillo T, De Luca Picione C, Saccà F, De Rosa A, Moccia M, BresciaMorra V, Matarese G. Immunometabolic profiling of patients with multiple sclerosis identifies new biomarkers to predict disease activity during treatment with interferon beta-1a. Clin Immunol. 2017 Oct;183:249-253;
  17. de Candia P, De Rosa V, Gigantino V, Botti G, Ceriello A, Matarese G. Immunometabolism of human autoimmune diseases: from metabolites to extracellular vesicles. FEBS Lett. 2017 Oct;591(19):3119-3134;
  18. De Rosa V, Di Rella F, Di Giacomo A, Matarese G. Regulatory T cells as suppressors of anti-tumor immunity: Role of metabolism. Cytokine Growth Factor Rev. 2017 Apr 11. pii: S1359-6101(17)30037-0.
  19. Melis D, Carbone F, Minopoli G, La Rocca C, Perna F, De Rosa V, Galgani M, Andria G, Parenti G, Matarese G. Cutting Edge: Increased Autoimmunity Risk in Glycogen Storage Disease Type 1b Is Associated with a Reduced Engagement of Glycolysis in T Cells and an Impaired Regulatory T Cell Function. J Immunol. 2017 Apr 7. pii: 1601946.
  20. Procaccini C, La Rocca C, Carbone F, De Rosa V, Galgani M, Matarese G. Leptin  as immune mediator: Interaction between neuroendocrine and immune system. Dev Comp Immunol. 2017 Jan;66:120-129.
  21. Carbone F, La Rocca C, De Candia P, Procaccini C, Colamatteo A, Micillo T, De  Rosa V, Matarese G. Metabolic control of immune tolerance in health and autoimmunity. Semin Immunol. 2016 Oct;28(5):491-504.
  22. Galgani M*, De Rosa V*, La Cava A, Matarese G. Role of Metabolism in the Immunobiology of Regulatory T Cells. J Immunol. 2016 Oct 1;197(7):2567-75. *(First Co-author).
  23. Procaccini C, Santopaolo M, Faicchia D, Colamatteo A, Formisano L, de Candia P, Galgani M, De Rosa V, Matarese G. Role of metabolism in neurodegenerative disorders. Metabolism 2016 Sep;65(9):1376-90.
  24. de Candia P, De Rosa V, Casiraghi M, Matarese G. Extracellular RNAs: a secret  arm of immune system regulation. J. Biol. Chem. 2016 Apr 1;291(14):7221-8;
  25.  Procaccini C, Carbone F, Di Silvestre D, Brambilla F, De Rosa V, Galgani M, Faicchia D, Marone G, Tramontano D, Corona M, Alviggi C, Porcellini A, La Cava A, Mauri P, Matarese G. The Proteomic Landscape of Human Ex Vivo Regulatory and Conventional T Cells Reveals Specific Metabolic Requirements. Immunity. 2016 Feb 16;44(2):406-21;
  26. Cantarini L, Pucino V, Vitale A, Talarico R, Lucherini OM, Magnotti F, De Rosa V, Galgani M, Alviggi C, Marone G, Galeazzi M, Matarese G. Immunometabolic biomarkers of inflammation in Behçet's disease: Relationship with epidemiological profile, disease activity and therapeutic regimes. Clin Exp Immunol. 2016 May;184(2):197-207;
  27.  Pucino V, Lucherini OM, Perna F, Obici L, Merlini G, Cattalini M, La Torre F,  Maggio MC, Lepore MT, Magnotti F, Galgani M, Galeazzi M, Marone G, De Rosa V, Talarico R, Cantarini L, Matarese G. Differential impact of high and low penetrance TNFRSF1A gene mutations on conventional and regulatory CD4+ T cell functions in TNFR1-associated periodic syndrome. J Leukoc Biol. 2016 May;99(5):761-9;
  28. De Rosa V, Galgani M, Santopaolo M, Colamatteo A, Laccetti R, Matarese G. Nutritional control of immunity: Balancing the metabolic requirements with an appropriate immune function. Semin. Immunol. 2015 Sep;27(5):300-9;
  29. De Rosa V, Galgani M, Porcellini A, Colamatteo A, Santopaolo M, Zuchegna C, Romano A, De Simone S, Procaccini C, La Rocca C, Carrieri PB, Maniscalco GT, Salvetti M, Buscarinu MC, Franzese A, Mozzillo E, La Cava A, Matarese G. Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3-exon 2 splicing variants. Nat. Immunol. 2015 Nov;16(11):1174-84;
  30. Galgani M*, De Rosa V*, Matarese G. T cell metabolism and susceptibility to autoimmune diseases. Mol Immunol. 2015 Aug 8. 68(2 Pt C):558-63. *(First Co-author);
  31. Procaccini C, De Rosa V, Pucino V, Formisano L, Matarese G. Animal models of Multiple Sclerosis. Eur J Pharmacol. 2015 Jul 15;759:182-91;
  32. Mauro C*, De Rosa V*, Marelli-Berg F, Solito E. Metabolic syndrome and the immunological affair with the blood-brain barrier. Front. Immunol. 2015 Jan 5;5:677. *(First Co-author)
  33. Cassano S, Pucino V, La Rocca C, Procaccini C, De Rosa V, Marone G, Matarese G. Leptin modulates autophagy in human CD4+CD25- conventional T cells. Metabolism. 2014 Oct;63(10):1272-9;
  34. Procaccini C, Pucino V, De Rosa V, Marone G, Matarese G. Neuro-endocrine networks controlling immune system in health and disease. Front. Immunol. 2014 Apr 7;5:143.
  35. Matarese G, Colamatteo A, De Rosa V. Metabolic fuelling of proper T cell functions. Immunol. Lett. 2014 Oct;161(2):174-8;
  36. Carbone F*, De Rosa V*, Carrieri PB, Montella S, Bruzzese D, Porcellini A, Procaccini C, La Cava A, Matarese G. Regulatory T cell proliferative potential is impaired in human autoimmune disease. Nat. Med. 2014 Jan;20(1):69-74. *(First Co-author);
  37. Procaccini C, De Rosa V, Galgani M, Carbone F, La Rocca C, Formisano L, Matarese G. Role of adipokines signaling in the modulation of T cells function. Front. Immunol. 2013 Oct 18;4:332.
  38. Matarese G, Procaccini C, Menale C, Kim JG, Kim JD, Diano S, Diano N, De Rosa V, Dietrich MO, Horvath TL. Hunger-promoting hypothalamic neurons modulate effector and regulatory T-cell responses. Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):6193-8;
  39. Galgani M, Nugnes R, Bruzzese D, Perna F, De Rosa V, Procaccini C, Mozzillo E, Cilio CM, Elding Larsson H, Lernmark A, La Cava A, Franzese A, Matarese G. Meta-immunological profiling of children with type 1 diabetes identifies new biomarkers to monitor disease progression. Diabetes. 2013 Jul;62(7):2481-91;
  40. Procaccini C, De Rosa V, Galgani M, Carbone F, Cassano S, Greco D, Qian K, Auvinen P, Calì G, Stallone G, Formisano L, La Cava A, Matarese G. Leptin-induced mTOR activation defines a specific molecular and transcriptional signature controlling CD4+ effector T cell responses. J. Immunol. 2012 Sep 15;189(6):2941-53;
  41. Matarese G, Procaccini C, De Rosa V. At the crossroad of T cells, adipose tissue, and diabetes. Immunol. Rev. 2012 Sep;249(1):116-34;
  42. Matarese G, De Rosa V. Ob-stopping obesity, metabolic and immune-mediated disorders. Structure. 2012 Mar 7;20(3):385-7;
  43. Procaccini C, Galgani M, De Rosa V, Matarese G. Intracellular metabolic pathways control immune tolerance. Trends Immunol. 2012 Jan;33(1):1-7;
  44. Procaccini C, Carbone F, Galgani M, La Rocca C, De Rosa V, Cassano S, Matarese G. Obesity and susceptibility to autoimmune diseases. Expert Rev. Clin. Immunol. 2011 May;7(3):287-94;
  45. Procaccini C*, De Rosa V*, Galgani M, Abanni L, Calì G, Porcellini A, Carbone F, Fontana S, Horvath TL, La Cava A, Matarese G. An oscillatory switch in mTOR kinase activity sets regulatory T cell responsiveness. Immunity. 2010 Dec 14;33(6):929-41. *(First Co-author);
  46. Galgani M, Procaccini C, De Rosa V, Carbone F, Chieffi P, La Cava A, Matarese G. Leptin modulates the survival of autoreactive CD4+ T cells through the nutrient/energy-sensing mammalian target of rapamycin signaling pathway. J. Immunol. 2010 Dec 15;185(12):7474-9;
  47. Matarese G, Carrieri PB, Montella S, De Rosa V, La Cava A. Leptin as a metabolic link to multiple sclerosis. Nat. Rev. Neurol. 2010 Aug;6(8):455-61;
  48. Matarese G, Procaccini C, De Rosa V, Horvath TL, La Cava A. Regulatory T cells in obesity: the leptin connection. Trends Mol. Med. 2010 Jun;16(6):247-56;
  49. Carbone F, Procaccini C, De Rosa V, Alviggi C, De Placido G, Kramer D, Longobardi S, Matarese G. Divergent immunomodulatory effects of recombinant and urinary-derived FSH, LH, and hCG on human CD4+ T cells. J. Reprod. Immunol. 2010 Jun;85(2):172-9;
  50. Procaccini C, Galgani M, De Rosa V, Carbone F, La Rocca C, Ranucci G, Iorio R, Matarese G. Leptin: the prototypic adipocytokine and its role in NAFLD. Curr. Pharm. Des. 2010 Jun;16(17):1902-12;
  51. Matarese G, Procaccini C, De Rosa V. The intricate interface between immune and metabolic regulation: a role for leptin in the pathogenesis of multiple sclerosis? J. Leukoc. Biol. 2008 Oct;84(4):893-9;
  52. Matarese G, De Rosa V, La Cava A. Regulatory CD4 T cells: sensing the environment. Trends Immunol. 2008 Jan;29(1):12-7;
  53. De Rosa V, Procaccini C, Calì G, Pirozzi G, Fontana S, Zappacosta S, La Cava A, Matarese G. A key role of leptin in the control of regulatory T cell proliferation. Immunity. 2007 Feb;26(2):241-55;
  54. Farooqi IS, Wangensteen T, Collins S, Kimber W, Matarese G, Keogh JM, Lank E, Bottomley B, Lopez-Fernandez J, Ferraz-Amaro I, Dattani MT, Ercan O, Myhre AG, Retterstol L, Stanhope R, Edge JA, McKenzie S, Lessan N, Ghodsi M, De Rosa V, Perna F, Fontana S, Barroso I, Undlien DE, O'Rahilly S. Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor. New Engl. J. Med. 2007 Jan 18;356(3):237-47;
  55. Chan JL, Matarese G, Shetty GK, Raciti P, Kelesidis I, Aufiero D, De Rosa V, Perna F, Fontana S, Mantzoros CS. Differential regulation of metabolic, neuroendocrine, and immune function by leptin in humans. Proc Natl Acad Sci U S A. 2006 May 30;103(22):8481-6;
  56. De Rosa V, Procaccini C, La Cava A, Chieffi P, Nicoletti GF, Fontana S, Zappacosta S, Matarese G. Leptin neutralization interferes with pathogenic T cell autoreactivity in autoimmune encephalomyelitis. J. Clin. Invest. 2006 Feb;116(2):447-55;
  57. Matarese G, Carrieri PB, La Cava A, Perna F, Sanna V, De Rosa V, Aufiero D, Fontana S, Zappacosta S. Leptin increase in multiple sclerosis associates with reduced number of CD4(+)CD25(+) regulatory T cells. Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5150-5;
  58. Galgani M, De Rosa V, De Simone S, Leonardi A, D' Oro U, Napolitani G, Masci AM, Zappacosta S, Racioppi L. Cyclic AMP modulates the functional plasticity of immature dendritic cells by inhibiting Src-like kinases through protein kinase A-mediated signaling. J. Biol. Chem. 2004 Jul 30;279(31):32507-14;
  59. Masci AM, Galgani M, Cassano S, De Simone S, Gallo A, De Rosa V, Zappacosta S, Racioppi L. HIV-1 gp120 induces anergy in naive T lymphocytes through CD4-independent protein kinase-A-mediated signaling. J. Leukoc. Biol. 2003 Dec;74(6):1117-24.
  • INTERNATIONAL BOOK CHAPTERS
  1. Pucino V, De Rosa V, Procaccini C, Matarese G. Regulatory T cells, leptin and angiogenesis. Angiogenesis, Lymphangiogenesis and Clinical Implications Chem. Immunol. Allergy. 2014;99:155-69;
  2. Matarese G, De Rosa V. Use of anti-leptin or anti-leptin receptor antibodies as blockers of immune response. Leptin and leptin antagonists. Landes Biosciences/Eurekah.com, Austin USA, 2009; 126.131.
  3. Matarese G., Procaccini C., De Rosa V. Leptin and immune function, inflammation and angiogenesis. Leptin: Endocrinology update series. Springer, Germany. 2007; 125-138;
  4. Matarese G, De Rosa V, Aufiero D, Procaccini C, Alviggi C, De Placido G, Fontana S, Zappacosta S. Immune response and metabolism: novel targets for future therapeutic strategies in inflammation and autoimmunity. Trends in Immunology Research. Nova Science Publishers, Inc. Hauppauge, NY, USA. 2005; 1-15.

 

  • COLLABORAZIONI INTERNAZIONALI
  • Prof. George Hajishengallis, Penn Dental Medicine, University of Pennsylvania, Philadelphia, USA;
  • Prof. Triantafyllos Chavakis, Institute for Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany;
  • Dr. Egle Solito, William Harvey Research Institute, Queen Mary University of London, London, UK;
  • Prof. Federica Marelli-Berg, William Harvey Research Institute, Queen Mary University of London, London, UK.


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