1. Mechanisms of DNA repair and Genome Stability.
2. Genome Instability in human cancers.
3. Molecular mechanisms and cellular functions of the post-translational protein modification ADP-ribosilation.
4. Modulating ADP-ribosilation enzymes to treat human diseases. 

For additional details, please visit our website: https://lucapalazzo6.wixsite.com/genomestabilityunit/

Education and Training:

• 2020-07-01 to present | Researcher - CNR Staff Scientist, Institute Experimental Endocrinology and Oncology, Naples, IT. 

• 2019-06-01 to 2020-06-30 | Research Associate, Institute Experimental Endocrinology and Oncology, Naples, IT. 

• 2018-06-01 to 2019-05-31 | Research Associate, Institute of Protein Biochemistry, Naples, IT. 

• 2015-01 to 2018-05 | Postdoctoral Fellow, Sir William Dunn School of Pathology, University of Oxford, Oxford, GB. 

• 2014-01 to 2015-01 | Postdoctoral Fellow funded by the Italian Foundation for Cancer Research (FIRC), Sir William Dunn School of Pathology, University of Oxford, Oxford, GB. 

• 2012-05 to 2012-05 | Visiting Scientist, Department of Microbiology and Immunology, Columbia University Medical Centre, New York, USA.

• 2011-08 to 2011-10 | Visiting Scientist, Clare Hall Laboratories, London Cancer Research UK Institute, London, GB. 

• 2011-01 to 2014-01 | Postdoctoral Fellow funded by the Italian Foundation for Cancer Research (FIRC), Department of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", Naples, IT. 

• 2011-01-20 | PhD in Molecular Oncology and Endocrinology,  Department of Cellular and Molecular Biology and Pathology, University of Naples "Federico II", Naples, IT. 

• 2007-09-27 | Master's degree in Medical Biotechnologies, Faculty of Biotechnologies Sciences, University of Naples "Federico II", Naples, IT.  

• 2005-10-25 | Bachelor's degree in Biotechnologies for Health, Faculty of Biotechnologies Sciences, University of Naples "Federico II", Naples, IT. 

Member of the following Scientific Societies: 

• 2017-09-04 to present | Early Career. American Society for Biochemistry and Molecular Biology: Rockville, MD, US. 

• 2017-09-01 to present | Full Member. Federation of European Biochemical Societies: Cambridge, GB. 

• 2017-09-01 to present | Full Member. Biochemical Society: London, London, GB. 

Prizes and Awards: 

• Article recommendation by the FACULTY OF 1000 (F1000) (Prokhorova E et al. Moll Cell. 2021) (June 2021).
• Awarded the “Collaborative Research Development Grant”, Ovarian Cancer Research Alliance (OCRA) (January 2021).
• Awarded the “Change Promoting Research Grant in Translational Research for Young Scientists”, Italian Ministry of Health (March 2019).
• Awarded the “Seal of Excellence: high-quality proposal in a highly competitive evaluation process”, Marie Skłodowska-Curie Actions (MSCA), European Community (March 2019).
• Article recommendation by the FACULTY OF 1000 (F1000) (Palazzo et al. Biochem J. 2015) (June 2015).
• Selected to support the Italian Association for Cancer Research (AIRC) fundraising campaign "In Viaggio con la Ricerca” (July 2014).
• Awarded the “FIRC fellowship for abroad”, a one-year postdoctoral fellowship funded by the Italian Foundation for Cancer Research (FIRC). Award: 14895 (November 2013).
• Awarded the “26 fellowship – FIRC”, a three-years postdoctoral fellowship funded by the Italian Foundation for Cancer Research (FIRC). Award: 11312 (November 2010).
• “EMBO travel grant for outstanding science” Award (June 2010).
• Awarded a PhD Scholarship in Molecular Oncology and Endocrinology, University of Naples “Federico II” (November 2007).

Reviewer for: 

• Nucleic Acids Research (ISSN 0305-1048)

• European Journal of Pharmacology (ISSN 0014-2999)

• British Journal of Cancer (ISSN 0007-0920)

• Cancer Letters (ISSN 0304-3835)

• Frontiers in Cell and Developmental Biology (ISSN 2296634X)

• Cancers (ISSN 2072-6694)

• Scientific Reports (ISSN 2045-2322)

• Challenges (ISSN 2078-1547)

• Cells (ISSN 2073-4409)

• Biochemistry and Cell Biology (ISSN 1208-6002)

• PeerJ (ISSN 2376-5992)

• External Expert and Reviewer for the European Commission

Member of the Editorial and Reviewing Board for: 

• Antibiotics (Topic Editor)

• Cancers (Reviewing Board)

•  Advances in Biochemistry (Editorial Board)

• Jacobs Journal of Biochemistry (Editorial Board)

Teaching Activities and Habilitations:

• Italian National Scientific Qualification (ASN) to compete for Associate Professorship in Molecular Biology (2019-09-11 to 2028-09-11).

• Italian National Scientific Qualification (ASN) to compete for Associate Professorship in General Pathology (2019-09-09 to 2028-09-09).

• Italian National Scientific Qualification (ASN) to compete for Associate Professorship in Biochemistry (2018-09-24 to 2027-09-24).

• Short-term Lecturer Teaching position – General Pathology, Faculty of Biotechnology Sciences, University of Naples “Federico II”, Italy (2009 to 2014).

• Palazzo, L., Suskiewicz, M.J., Ahel, I. Serine ADP-ribosylation in DNA-damage response regulation. Curr Opin Genet Dev. 2021 Jul 30;71:106-113.
• Prokhorova, E., Agnew, T., Wondisford, A.R., Tellier, M., Kaminski, N., Beijer, D., Holder, J., Groslambert, J., Suskiewicz, M.J., Zhu, K., Reber, J.M., Krassnig, S.C., Palazzo, L., Murphy, S., Nielsen, M.L., Mangerich, A., Ahel, D., Baets, J., O'Sullivan, R.J., Ahel, I. Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease. Mol Cell. 2021 May 12:S1097-2765(21)00357-9. 
• Suskiewicz, M.J., Palazzo, L., Hughes, R., Ahel, I. Progress and outlook in studying the substrate specificities of PARPs and related enzymes. FEBS Journal, 2021, 288(7), pp. 2131–2142.
• Poltronieri, P., Celetti, A., Palazzo, L. Mono(ADP-ribosyl)ation Enzymes and NAD+ Metabolism: A Focus on Diseases and Therapeutic Perspectives. Cells, 2021, 10(1).
• Morra, F., Merolla, F., Picardi, I., Russo, D.,Ilardi, G., Varricchio, S., Liotti, F., Pacelli, R., Palazzo, L., Mascolo, M., Celetti, A., Staibano, S. CAF-1 subunits levels suggest combined treatments with PARP-inhibitors and ionizing radiation in advanced HNSCC. Cancers, 2019; 11(10), 1582.
• Rack, J.G.M*., Palazzo, L*., Ahel, I. (ADP-ribosyl)hydrolases: Structure, function, and biology. Genes and Development. 2020; 34(5), pp. 263-284. (*equal contribution).
• Catara, G., Corteggio, A., Valente, C., Grimaldi, G., Palazzo, L.  Targeting ADP-ribosylation as an antimicrobial strategy. Biochemical Pharmacology. 2019; 167, pp. 13-26.
• Palazzo, L.,  Leidecker, O.,  Prokhorova, E.,  Dauben, H.,  Matic, I. Ahel, I. eLife. 2018; 7,e34334 
• Fontana, P.*, Bonfiglio, J.J.*, Palazzo, L.*, Bartlett, E., Matic, I., Ahel, I. Serine ADP-ribosylation reversal by the hydrolase ARH3. eLife. 2017; 6,e28533. (*equal contribution).
• Lalić, J.*,  Marjanović, M.P.*,  Palazzo, L.*,  Perina, D.,  Sabljić, I.,  Žaja, R.,  Colby, T.,  Pleše, B.,  Halasz, M.,  Jankevicius, G.,  Bucca, G.,  Ahel, M.,  Matič, I.,  Četković, H.,  Luić, M.,  Mikoç, A., Ahel, I. Disruption of macrodomain protein SCO6735 increases antibiotic production in streptomyces coelicolor. Journal of Biological Chemistry. 2016; 291(44), pp. 23175-23187. (*equal contribution).
• Leidecker, O.,  Bonfiglio, J.J.,  Colby, T.,  Zhang, Q.,  Atanassov, I.,  Zaja, R.,  Palazzo, L.,  Stockum, A.,  Ahel, I.,  Matic, I. Serine is a new target residue for endogenous ADP-ribosylation on histones. Nature Chemical Biology. 2016; 12(12), pp. 998-1000. 
• Palazzo, L., Thomas, B., Jemth, A.-S., Colby, T., Leidecker, O.,  Feijs, K.L.H.,  Zaja, R.,  Loseva, O.,  Vert, J.C.,  Matic, I.,  Helleday, T.,  Ahel, I. Processing of protein ADP-ribosylation by Nudix hydrolases. Biochemical Journal. 2015; 468(2), pp. 293-301.

• Dr. Ivan Ahel, Università di Oxford, Oxford, Regno Unito.
• Dr. Angela Celetti, IEOS-CNR, Napoli, Italia. 
• Dr. Roberta VIsconti, IEOS-CNR, Napoli, Italia. 
• Prof. Caterina Missero, Università degli Studi di Napoli "Federico II", Napoli, Italia.
• Prof. Maria Letizia Barreca, Università di Perugia, Perugia, Italia.
• Dr. Roman Fischer, Università di Oxford, Oxford, Regno Unito.
• Prof. Enrico Vittorio Avvedimento, Università degli Studi di Napoli "Federico II", Napoli, Italia.
• Prof. Ahmed Ahmed, Università di Oxford, Oxford, Regno Unito.
• Dr. Scott H. Kaufmann, Mayo Clinic, USA.