2007-’16 Senior Researcher (Primo Ricercatore) at the Istituto di Endocrinologia e Oncologia Sperimentale-Consiglio Nazionale delle Ricerche (IEOS-CNR), Italy. Main project: the genetic of type 2 diabetes mellitus. Specific fields of interest: molecular mechanisms of hyperglycemia-induced insulin-resistance and beta-cell disfunction. In vivo models of insulin-resitance.

2014 - National Scientific Habilitation to Full Professor of Applied Biology

Selected for the presentation lecture in the application procedure for W2 Professorship for Pharmacogenetics of Type 2 Diabetes at the Faculty of Sciences, Institute of Pharmacy and Biochemistry, at the University of Tübingen, Germany.

2001-’07 Researcher at the Istituto di Endocrinologia e Oncologia Sperimentale-Consiglio

Nazionale delle Ricerche (IEOS-CNR), Italy.

Main project: the genetic of type 2 diabetes mellitus. Specific fields of interest:

regulation of beta-cells functions, glucose metabolism.

2001- Ph.D in Pathology and Clinic of Vascular Diseases.

1998-’00 “Poste Vert” fellow at the Unite 145 - (INSERM), Nice, France, working on molecular mechanism of diabetic complications.

1995-’97 Visiting-fellow at the Unite 145 - Institut National de la Santé et de la Recherche

Medicale (INSERM), Nice, France (october-december 1995, april-june 1996.

august-september 1997), working on insulin receptor signalling.

1990-’95 Fellow at the Department of Cellular and Molecular Biology and Pathology,

University of Naples "Federico II", Italy, working on insulin receptor signalling.

1989 - Degree in Natural Science, December 1989.

GRANTS, AWARDS

2015-‘17 Grant EFSD/Novo Nordisk Programme for Diabetes Research in Europe. Title:” Impaired angiogenesis in Diabetes: unravelling the role of Glyoxalase 1 and methylglyoxal”

2013- Grant SID-FO.DI.RI 2013-2015 Title: “The role of methylglyoxal in the pathogenesis of insulin-resistance and endothelial disfunction in Type 2 Diabetes.”

2011-’13 Grant PRIN annualità 2009 - PROT. 2008NAXY92_004 Title: “Il Ruolo Degli

Ages (Advanced Glycation End Products) Nella Patogenesi Del Danno

Vascolare Nel Diabete Tipo 2”

2007-09 Grant EFSD/GlaxoSmithKline Programme for the Study of Metabolic Toxicity in

Diabetes. Title: “The role of endoplasmic reticulum stress in the insulinresistance induced by chronic hyperglycaemia”

Grant from CNR Progetto ricerca spontanea a tema libero (RSTL) “il ruolo del

gene ped/pea-15 nel controllo della funzione beta cellulare e nel diabete tipo 2

2000-’01 Grant from Univesity of Naples “Federico II” title: “La Tessuto-Specificità Della

Trasmissione Del Segnale Dell’insulina”

1998- “Poste Vert” fellowship of the Institut National de la Santé et de la

Recherche Medicale (INSERM), Nice, France

1997- University of Naples "Federico II" fellowship.

1994-’96 Italian Association for Cancer Research (A.I.R.C.) fellowship, january 1994-

december 1996.

1993- A.Menarini-Bristol Myers Squibb fellowship, september-december 1993.

Mirra P, Nigro C, Prevenzano I, Procopio T, Leone A, Raciti GA, Andreozzi F, Longo M, Fiory F, Beguinot F, Miele C. The role of miR-190a in methylglyoxal-induced insulin resistance in endothelial cells. Biochim Biophys Acta. 2017 Feb;1863(2):440-449. doi: 10.1016/j.bbadis.2016.11.018.
Raciti GA, Longo M, Parrillo L, Ciccarelli M, Mirra P, Ungaro P, Formisano P, Miele C, Beguinot F. Understanding type 2 diabetes: from genetics to epigenetics. Acta Diabetol. 2015 Oct;52(5):821-7. doi: 10.1007/s00592-015-0741-0.
Mirra P, Raciti GA, Nigro C, Fiory F, D'Esposito V, Formisano P, Beguinot F, Miele C. Circulating miRNAs as intercellular messengers, potential biomarkers and therapeutic targets for Type 2 diabetes. Epigenomics. 2015;7(4):653-67. doi: 10.2217/epi.15.18.
Nigro C, Raciti GA, Leone A, Fleming TH, Longo M, Prevenzano I, Fiory F, Mirra P, D'Esposito V, Ulianich L, Nawroth PP, Formisano P, Beguinot F, Miele C. Methylglyoxal impairs endothelial insulin sensitivity both in vitro and in vivo. Diabetologia. 2014 Jul;57(7):1485-94. doi: 10.1007/s00125-014-3243-7.
Fiory F, Parrillo L, Raciti GA, Zatterale F, Nigro C, Mirra P, Falco R, Ulianich L, Di Jeso B, Formisano P, Miele C, Beguinot F. PED/PEA-15 inhibits hydrogen peroxide-induced apoptosis in Ins-1E pancreatic beta-cells via PLD-1. PLoS One. 2014 Dec 9;9(12):e113655. doi: 10.1371/journal.pone.0113655.
Cassese A, Raciti GA, Fiory F, Nigro C, Ulianich L, Castanò I, D'Esposito V, Terracciano D, Pastore L, Formisano P, Beguinot F, Miele C. Adenoviral gene transfer of PLD1-D4 enhances insulin sensitivity in mice by disrupting phospholipase D1 interaction with PED/PEA-15. PLoS One. 2013 Apr 9;8(4):e60555.
Santulli G, Lombardi A, Sorriento D, Anastasio A, Del Giudice C, Formisano P, Béguinot F, Trimarco B, Miele C, Iaccarino G. Age-related impairment in insulin release: the essential role of β(2)-adrenergic receptor. Diabetes. 2012 Mar;61(3):692-701. doi: 10.2337/db11-1027.
Raciti GA, Iadicicco C, Ulianich L, Vind BF, Gaster M, Andreozzi F, Longo M, Teperino R, Ungaro P, Di Jeso B, Formisano P, Beguinot F, Miele C. Glucosamine-induced endoplasmic reticulum stress affects GLUT4 expression via activating transcription factor 6 in rat and human skeletal muscle cells. Diabetologia. 2010 May;53(5):955-65. doi: 10.1007/s00125-010-1676-1.
Cassese A, Esposito I, Fiory F, Barbagallo AP, Paturzo F, Mirra P, Ulianich L, Giacco F, Iadicicco C, Lombardi A, Oriente F, Van Obberghen E, Beguinot F, Formisano P, Miele C. In skeletal muscle advanced glycation end products (AGEs) inhibit insulin action and induce the formation of multimolecular complexes including the receptor for AGEs. J Biol Chem. 2008 Dec 26;283(52):36088-99. doi: 10.1074/jbc.M801698200

Miele C, Raciti GA, Cassese A, Romano C, Giacco F, Oriente F, Paturzo F, Andreozzi F, Zabatta A, Troncone G, Bosch F, Pujol A, Chneiweiss H, Formisano P, Beguinot F. PED/PEA-15 regulates glucose-induced insulin secretion by restraining potassium channel expression in pancreatic beta-cells. Diabetes. 2007 Mar;56(3):622-33.